The present study was conducted with the aim of investigating the effectiveness of combined compassion-focused therapy and acceptance and commitment therapy on Adherence to treatment and Parenting Stress in mothers of autistic children in Khomeinishahr city in 2023. The research was semi-experimental in the form of pre-test-post-test with a control group. In this research, the purposeful sampling method was used, and from the statistical population, which consisted of all mothers with autistic children in Khomeinishahr, whose children were being educated at the Sarai Pakan center, 30 people were selected based on the inclusion criteria and randomly replaced in two experimental and control groups. The tools were Parental Stress Questionnaire (PSI) (Abidin, 2018) and Adherence to treatment Questionnaire (Madanlu, 2012). After the pre-test, the experimental group was trained in 10 sessions of 90 minutes. Then, both groups were re-evaluated; The results were analyzed with spss software and covariance method. The results showed that the implemented treatment had an effect on the Adherence to treatment and parental tension in the post-test stage and the changes in the experimental group were statistically significant compared to the control group. (P<0.05) Also, the treatment was effective on the components of adherence to the treatment, integration with life, commitment to treatment and resourcefulness in the implementation of the treatment, and also on the components of parental stress, except relations with spouse, competence, depression, social isolation and reinforcement have been significant.
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